Nature of Slovácko is very varied. It includes mountain meadows and woods, dry limestone rocks, ponds and flooded forests. Thanks to their qualities, three Protected Landscape Areas - Bílé Karpaty (White Carpathians), Pálava (Pálava Hills) and Lednicko-valtický areál (Lednice-Valtice Area) - have been incorporated in the lists of the world organization UNESCO.

The eastern part of Slovácko is formed by Bílé Karpaty with their typical features: gradual ridges, meadows with numerous species and groups of lonely standing trees and characteristic villages with distinctive folk architecture. The axis of Slovácko is formed by a wide valley of the river Morava (Moravia). In the surroundings of Strážnice, Mikulčice and Lanžhot, unique flooded forests have been preserved till now. In addition to rare plants and animals, beech woods of Chřiby (Chřiby Hills) and Ždánický les (Ždánický Forest) in the northwest also conceal many places with a beautiful view. In the vicinity of the second important river - Dyje - there are two notable areas on the south edge of Slovácko: Pálava and Lednicko-valtický areál. Pálava is the home of thermophilic plants and animals living in limestone rocks, steppes and forest steppes. Lovers of nature know Lednicko-valtický areál mainly thanks to the network of Lednice ponds, which represent an ornithological locality of international importance.

In Slovácko, lovers of nature will find a network of tourist marked trails both for walkers and cyclists, interpretive trails introducing the major sights and some nature-scientific expositions.